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Evidence for effect of l-serine, a novel therapy for GRIN2B-related neurodevelopmental disorder.

B. den Hollander; A.R.J. Veenvliet; Marieke Lindenschot; P. van Essen; G. Peters; A. Santos-Gómez; M. Olivella; X. Altafaj; M.M. Brands; B.A.W. Jacobs; C.D. van Karnebeek

RATIONALE: To date, causal therapy is potentially available for GRIN2B-related neurodevelopmental disorder (NDD) due to loss-of-function (LoF) variants in GRIN2B, resulting in dysfunction of the GluN2B subunit-containing N-methyl-d-aspartate receptor (NMDAR). Recently, in vitro experiments showed that …

2023AlgemeenArtikel

Physiotherapy with integrated virtual reality for patients with complex chronic low back pain: protocol for a pragmatic cluster randomized controlled trial (VARIETY study).

S. Slatman; R. Ostelo; H. van Goor; Bart Staal; J. Knoop

BACKGROUND: Chronic low back pain (CLBP) is the most common chronic pain condition worldwide. Currently, primary care physiotherapy is one of the main treatment options, but effects of this treatment are small. Virtual Reality (VR) could be an adjunct to physiotherapy care, due to its multimodal features. …

2023AlgemeenArtikel

Activating Relatives to Get Involved in Care After Surgery: Protocol for a Prospective Cohort Study

Musters, Selma C W; Kreca, Sani; van Dieren, Susan; van der Wal-Huisman, Hanneke; Romijn, Johannes A; Chaboyer, Wendy; Nieveen van Dijkum, Els J M; Eskes, Anne M (Lectoraat Patiënt- En Familieparticipatie In De Klinische Zorg)

Background: Postoperative complications and readmissions to hospital are factors known to negatively influence the short- and long-term quality of life of patients with gastrointestinal cancer. Active family involvement in activities, such as fundamental care activities, has the potential to improve …

2023AlgemeenArtikel

Recommendations for an exercise intervention and core outcome set for older patients after hospital discharge: Results of an international Delphi study

Aarden, Jesse J. (Faculteit Gezondheid); Major, Mel E. (Centre Of Expertise Urban Vitality); Aghina, Claartje M. W.; van der Esch, Martin (Lectoraat Interdisciplinaire Zorg Voor Chronische Gewrichtsaandoeningen); Buurman, Bianca M; Engelbert, Raoul H. H. (Lectoraat Fysiotherapie - Transitie Van Zorg Bij Complexe Patiënten); van der Schaaf, Marike (Lectoraat Revalidatie In De Acute Zorg)

For older adults, acute hospitalization is a high-risk event with poor health outcomes, including functional decline. In absence of practical guidelines and high quality randomized controlled trials, this Delphi study was conducted. The aim of this study was to obtain consensus on an exercise intervention …

2023AlgemeenArtikel

Open or closed suctioning in invasively ventilated patients for sustainibility of ICU care?

Stilma, W. (Centre Of Expertise Urban Vitality); Esmeijer, A.; Paulus, F. (Lectoraat Critical Care); Frenzel, T.; Touw, H.; Stobernack, T.

2023AlgemeenConferentiebijdrage

More older adults died at their preferred place after implementation of a transmural care pathway for older adults at the end of life

van Doorne, Iris (Faculteit Gezondheid); de Meij, Marike A.; Parlevliet, Juliette L.; van Schie, Vera M. W.; Willems, Dick L.; Buurman, Bianca M.; van Rijn, Marjon (Lectoraat Geïntegreerde Complexe Zorg)

Background To improve transmural palliative care for older adults acutely admitted to hospital, the PalliSupport intervention, comprising an educational programme and transmural palliative care pathway, was developed. This care pathway involves timely identification of palliative care needs, advance …

2023AlgemeenArtikel

Feasibility of home-based cardiac rehabilitation in frail older patients: a clinical perspective

Terbraak, Michel; Verweij, Lotte; Jepma, Patricia; Buurman, Bianca; Jørstad, Harald; Scholte Op Reimer, Wilma; van der Schaaf, Marike (Lectoraat Revalidatie In De Acute Zorg)

(A) BACKGROUND: Home-based cardiac rehabilitation (CR) is an attractive alternative for frail older patients who are unable to participate in hospital-based CR. Yet, the feasibility of home-based CR provided by primary care physiotherapists (PTs) to these patients remains uncertain. (B) OBJECTIVE: To …

2023AlgemeenArtikel

Mechanical insufflation-exsufflation for invasively ventilated critically ill patients

Stilma, Willemke (Faculteit Gezondheid); Verweij, Lotte; Spek, Bea; Scholte Op Reimer, Wilhelmina Johanna Maria; Schultz, Marcus Josephus; Paulus, Frederique (Lectoraat Critical Care); Rose, Louise

INTRODUCTION: Mechanical Insufflation-Exsufflation (MI-E) is used as an airway clearance intervention in primary care (home ventilation), long-term care (prolonged rehabilitation after intensive care, neuromuscular diseases, and spinal cord injury), and increasingly in acute care in intensive care units …

2023AlgemeenArtikel

The Observable Movement Quality scale for patients with low back pain (OMQ-LBP): validity and reliability in a primary care setting of physical therapy

van Dijk, M. J. H.; van der Wal, A. M.; Mollema, J.; Visser, B.; Kiers, H.; Heerkens, Y.; Nijhuis-van der Sanden, M. W. G.

Background The Observable Movement Quality scale for patients with low back pain (OMQ-LBP) is a newly developed measurement instrument for use in primary care settings of physical and exercise therapists to assess movement quality (MQ) of patients with low back pain (LBP). Objective This study aims to …

2023AlgemeenArtikel

Translating Evidence from Dutch Exercise Oncology Trials in Patients with Breast Cancer into Clinical Practice Using the RE-AIM Framework

Ten Tusscher, Marieke R.; Stuiver, Martijn M. (Lectoraat Functioneel Herstel Bij Kanker); Kampshoff, Caroline S.; Huijsmans, Rosalie J.; Aaronson, Neil K.; Velthuis, Miranda; Gal, Roxanne; Van Waart, Hanna; May, Anne M.; Buffart, Laurien M.

Purpose. We aimed to evaluate the potential for implementing exercise interventions for patients with breast cancer in the Netherlands, based on findings of the Dutch randomized controlled trials in this population. Methods. We evaluated the implementation of four Dutch exercise trials retrospectively, …

2023AlgemeenArtikel

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