BACKGROUND: Although physical activity is beneficial for Parkinson's disease (PD) patients, many do not meet the recommended levels. The range of physical activity among sedentary PD patients is unknown, as are factors that determine this variability. Hence, we aimed to (1) assess daily physical activity …

ICT Automatisering is a Dutch company. The main expertises of ICT are portal & application development, embedded software development, and industrial automation. The company aims to have the leading-edge technology to ensure its competitiveness, which can be seen in this graduation project. The project …

Heme is a suggested limiting factor in peroxidase production by Aspergillus spp., which are well-known suitable hosts for heterologous protein production. In this study, the role of genes coding for coproporphyrinogen III oxidase (hemF) and ferrochelatase (hemH) was analyzed by means of deletion and …

On 26 January 1998, during a press conference in the White House, President Bill Clinton famously told the nation, "I did not have sexual relations with that woman, Miss Lewinsky" (Clinton, 1998). Now, 15 years later, almost everyone can still recall those famous words. In this dissertation, the interaction …

European tourism destinations are confronted with a trend toward increased environmental responsible behaviour. This trend seeks to improve the quality of life within those destinations for residents and tourists equally. Relating this subject to the principle of sustainable development, tourism destination …

BACKGROUND Patients experience a difference in the structure provided by the Dutch Asthma centre Davos (Nederlands Astmacentrum Davos; NAD) and the structure of their own environment in the Netherlands. They therefore find it difficult to transfer the 'new' behavior patterns and the knowledge they gained …

Horizontal collaborative purchasing (HCP) has often been cited as a way for hospitals to address the challenges of the rising healthcare costs. However, hospitals do not seem to utilize horizontal collaborative purchasing on any large scale, and recent initiatives have had mixed results. Focusing on …

One of the areas that is included in facility management is relocation and move management. This exploratory research focuses on the relocation of nursing home residents and the influence on their wellbeing. As other organizations, nursing homes do change over time. Such changes may include reorganizations, …

tIn this study we aimed to identify genes that are responsive to pertussis toxin (PTx) and might eventu-ally be used as biological markers in a testing strategy to detect residual PTx in vaccines. By microarrayanalysis we screened six human cell types (bronchial epithelial cell line BEAS-2B, fetal lung …

Glucocorticoids (GCs) such as prednisolone are potent immunosuppressive drugs but suffer from severe adverse effects, including the induction of insulin resistance. Therefore, development of so-called Selective Glucocorticoid Receptor Modulators (SGRM) is highly desirable. Here we describe a non-steroidal …