tIn this study we aimed to identify genes that are responsive to pertussis toxin (PTx) and might eventu-ally be used as biological markers in a testing strategy to detect residual PTx in vaccines. By microarrayanalysis we screened six human cell types (bronchial epithelial cell line BEAS-2B, fetal lung …

Glucocorticoids (GCs) such as prednisolone are potent immunosuppressive drugs but suffer from severe adverse effects, including the induction of insulin resistance. Therefore, development of so-called Selective Glucocorticoid Receptor Modulators (SGRM) is highly desirable. Here we describe a non-steroidal …

Basophils account for only 0.1-1% of all peripheral blood leukocytes. They were considered to be a redundant cell type for a long time. However, several findings show a non-redundant role for basophils in type 2 T-helper cell (Th2) immune responses in helminth infections, allergy and autoimmunity. Both …

Our conception of the brain is influenced by metaphors like the computer which grant the brain an executive function. This notion ignores the fact that the brain evolved in the context of the natural environment and functions together with it. In addition, we are frequently less aware of the action-perception …

BACKGROUND: T lymphocytes are orchestrators of adaptive immunity. Naïve T cells may differentiate into Th1, Th2, Th17 or iTreg phenotypes, depending on environmental co-stimulatory signals. To identify genes and pathways involved in differentiation of Jurkat T cells towards Th1 and Th2 subtypes we performed …

Toekomstbestendige business modellen voor mediadiensten zijn lastig te ontwikkelen door het adembenemend tempo waarin de markt zich vernieuwt. Als ondernemer wil je weten welke concepten werken én standhouden. Ondernemers zijn continue op zoek naar het vergroten van het rendement op hun media investeringen. …

Laboratory research was done on flat glass substrates to study the effect that brine salinity has on adhesion mechanisms between oil and clay particles. This is done by evaporating a small clay suspension droplet (6 ul) on a glass slide that leaves a thin layer of clay upon which oil can be attached. …

Fuel cell hybrid vehicles are believed to provide a solution to cut down emissions in the long term. They provide local zero-emission propulsion and when the hydrogen as fuel is derived from renewable energy sources, fuel cell hybrids enable well-to-wheel zero-emission transportation, …

The objective of an energy management strategy for fuel cell hybrid propulsion systems is to minimize the fuel needed to provide the required power demand. This minimization is defined as an optimization problem. Methods such as dynamic programming numerically solve this optimization problem. Strategies …