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Intramuscular short-chain acylcarnitines in elderly people are decreased in (pre-)frail females, but not in males

Hoek, M.D. van der; Nieuwenhuizen, A.G.; Kuda, O.; Bos, P.; Paluchová, V.; Verschuren, L. ; Hoek, A.M. van den; Kleemann, R.; Veeger, N.J.G.M. ; Leij, F.R. van der (Lector); Keijer, J.

This study tested the hypothesis that in human aging, a decreased intramuscular acylcarnitine status is associated with (pre-)frailty, reduced physical performance, and altered mitochondrial function. We used a cross-sectional study design with well-matched fit and (pre-)frail old males and females, …

2020-06-15GezondheidArtikel

Intramuscular short-chain acylcarnitines in elderly people are decreased in (pre-)frail females, but not in males.

Marjanne van der Hoek (Onderzoeker); Arie Nieuwenhuizen (Onderzoeker); Ondřej Kuda (Onderzoeker); Paul Bos (Onderzoeker); Veronika Paluchová (Onderzoeker); Lars Verschuren (Onderzoeker); Anita van den Hoek (Onderzoeker); Robert Kleemann (Onderzoeker); Nic Veeger (Onderzoeker); Feike van der Leij (Lector); Jaap Keijer (Onderzoeker)

We tested the hypothesis that in human ageing a decreased intramuscular acylcarnitine status is associated with (pre-)frailty, reduced physical performance and altered mitochondrial function. Results showed that intramuscular total carnitine levels and acetylcarnitine levels were lower in (pre-)frail …

2020-06-15GezondheidArtikel

Identifying critically ill patients with low muscle mass

Looijaard, Willem G.P.M.; Stapel, Sandra N.; Dekker, Ingeborg M.; Rusticus, Hanna; Remmelzwaal, Sharon; Girbes, Armand R.J.; Weijs, Peter J.M.; Oudemans-van Straaten, Heleen M.

Background & aims: Low muscle mass and -quality on ICU admission, as assessed by muscle area and -density on CT-scanning at lumbar level 3 (L3), are associated with increased mortality. However, CT-scan analysis is not feasible for standard care. Bioelectrical impedance analysis (BIA) assesses body …

2020-06AlgemeenArtikel

Knee extensor muscle steadiness in relation to maximal torque and physical functioning in patients with knee osteoarthritis

Satam, A.; Van der Leeden, M.; De Zwart, A.; Verberne, S.; Schrijvers, J.; Dekker, J.; Lems, W.; Haarlaar, J.; Van der Esch, M. (Lectoraat Interdisciplinaire Zorg Voor Chronische Gewrichtsaandoeningen)

2020-06AlgemeenArtikel

Steps to recovery

Kwakman, Robin C.H. (Faculteit Gezondheid); Sommers, Juultje; Horn, Janneke; Nollet, Frans; Engelbert, Raoul H.H. (Centre Of Expertise Urban Vitality); van der Schaaf, Marike (Centre Of Expertise Urban Vitality)

BACKGROUND: Early mobilization has been proven effective for patients in intensive care units (ICUs) to improve functional recovery. However, early mobilization of critically ill, often mechanically ventilated, patients is cumbersome because of the attachment to tubes, drains, monitoring devices and …

2020-05-15AlgemeenArtikel

Healthy subjects with lax knees use less knee flexion rather than muscle control to limit anterior tibia translation during landing

Keizer, Michèle N J; Hijmans, Juha M; Gokeler, Alli; Benjaminse, Anne; Otten, Egbert

PURPOSE: It has been reported that there is no correlation between anterior tibia translation (ATT) in passive and dynamic situations. Passive ATT (ATTp) may be different to dynamic ATT (ATTd) due to muscle activation patterns. This study aimed to investigate whether muscle activation during jumping …

2020-05-15AlgemeenArtikel

Inconsistent descriptions of lumbar multifidus morphology: A scoping review

Hofste, A (Anke) (Phd)

Background: Lumbar multifidus (LM) is regarded as the major stabilizing muscle of the spine. The effects of exercise therapy in low back pain (LBP) are attributed to this muscle. A current literature review is warranted, however, given the complexity of LM morphology and the inconsistency of anatomical …

2020-05-01AlgemeenArtikel

Changes in inflammation and musculoskeletal tissue-derived biomarker serum levels in response to high- and low-intensity resistance training in individuals with knee osteoarthritis

Jansen, N.E.; Engstrøm, A.; Thudium, C.S.; Bay-Jensen, A-C.; de Zwart, A.H.; Dekker, J.; Lems, W.F.; Gerritsen, M.; van Spil, W.E.; Jaspers, R.T.; Turkstra, F.; van der Leeden, M.; van der Esch, M. (Lectoraat Interdisciplinaire Zorg Voor Chronische Gewrichtsaandoeningen)

Purpose: Exercise therapy with a focus on muscle strengthening has proven to be effective for the management of knee osteoarthritis (OA). Yet it is not known whether high-intensity resistance training (RT) is more effective in improving upper leg muscle strength and physical performance than low-intensity …

2020-04AlgemeenArtikel

The effect of perceived knee joint instability on responses to external perturbations during gait in patients with knee osteoarthritis

Schrijvers, J.; van den Noort, J.; van der Esch, M. (Lectoraat Interdisciplinaire Zorg Voor Chronische Gewrichtsaandoeningen); Harlaar, J.

Purpose: Instability of the knee joint is reported by a majority (>65%) of patients with knee osteoarthritis (KOA) and is hypothesized to play a crucial role in the initiation and progression of KOA. A generally accepted objective metric of knee joint stability is lacking, making development of diagnostics …

2020-04AlgemeenArtikel

Is a model of stratified exercise therapy by physical therapists in primary care feasible in patients with knee osteoarthritis?

Knoop, J.; van der Leeden, M.; van der Esch, M. (Centre Of Expertise Urban Vitality); de Rooij, M.; Peter, W.F.; Bennell, K.L.; Steultjens, P.M.; Hakkinen, A.; Roorda, L.D.; Lems, W.F.; Dekker, J.

OBJECTIVES: To explore the feasibility of a newly developed model of stratified exercise therapy in primary care for patients with knee osteoarthritis (OA). DESIGN: Mixed method design (process, outcome and qualitative evaluation). SETTING: Six physical therapy practices in primary care around Amsterdam. …

2020-03AlgemeenArtikel

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