Accurate assessment of TP53 gene status in sporadic tumors and in the germline of individuals at high risk of cancer due to Li–Fraumeni Syndrome (LFS) has important clinical implications for diagnosis, surveillance, and therapy. Genomic data from more than 20,000 cancer genomes provide a wealth of information …

Background: Cross-cultural adaptation of health-related quality of life (HRQL) scales is useful as it allows comparisons of therapy outcomes across different countries to be drawn. Aims: To adapt the English Stroke and Aphasia Quality of Life—39 item generic stroke scale (SAQOL-39g) into Dutch. To …

This study examined if a macro-, meso-, and micro outcome measurement instrument that constitutes the evaluation stage of a Dutch forensic psychiatric outcome monitor, the Hoeven Outcome Monitor (HOM), can provide a first step towards a more evidence based groundwork in forensic mental health. General, …

Eighteen years after the introduction of the graphing calculator in national examinations in the Netherlands, much has been learned about the use of technology in education. One of the key lessons was that integrating ICT as a tool for learning math is a complex task, and this complexity is often underestimated. …

Objective In order to deliver good healthcare quality, it should explicitly be taken into account what patients value in healthcare. This study reviews qualitative studies in which patients express what they value. Based on this body of literature a preliminary taxonomy is designed. Methods A systematic …

Institutions such as governmental and scientific organizations share information to gain the public trust. Information sharing, on the other hand, may cause privacy breaches and undermine the stakeholders' trust in such information sharing institutions. Thus, information sharing may work against the …

Objectives Musculoskeletal pain has major public health implications, but the theoretical framework remains unclear. It is hypothesized that sensorimotor incongruence (SMI) might be a cause of long‐lasting pain sensations in people with chronic musculoskeletal pain. Research data about experimental …

Introduction. Despite the high number of inactive patients with COPD, not all inactive patients are referred to physical therapy, unlike recommendations of general practitioner (GP) guidelines. It is likely that GPs take other factors into account, determining a subpopulation that is treated by a physical …

Currently, 4% of older adults reside in long-term care facilities in the Netherlands. Nursing home residents tend to have multimorbidity that is associated with considerable disabilities and a high level of care dependency. In the Dutch adult population the highest …

Background: Screening and brief interventions (SBI) in primary healthcare are cost-effective in risky drinkers, yet they are not offered to all eligible patients. This qualitative study aimed to provide more insight into the factors and mechanisms of why, how, for whom and under what circumstances implementation …