Designing lead-free piezoelectric ceramics with tailored electrical properties remains a critical challenge for various applications. In this paper we present a novel methodology integrating Machine Learning (ML) and optimization procedures to fine-tune electrical properties in lead-free (1-x) Na0.5 …

Objective To develop and internally validate a prognostic model to predict chronic pain after a new episode of acute or subacute non-specific idiopathic, non-traumatic neck pain in patients presenting to physiotherapy primary care, emphasising modifiable biomedical, psychological and social factors. Design …

A bottleneck in restoring self-sustaining beds of the European oyster (Ostrea edulis) is the successful development and settlement of larvae to bottom habitats. These processes are largely governed by temperature but a mechanistic understanding of larval performance across ecologically relevant temperatures …

The search for existing non-animal alternative methods for use in experiments is currently challenging because of the lack of both comprehensive structured databases and balanced keyword-based search strategies to mine unstructured textual databases. In this paper we describe 3Ranker, which is a fast, …

BACKGROUND: The evidence on prophylactic use of negative pressure wound therapy on primary closed incisional wounds (iNPWT) for the prevention of surgical site infections (SSI) is confusing and ambiguous. Implementation in daily practice is impaired by inconsistent recommendations in current international …

Sepsis is a life-threatening organ dysfunction caused by a dysregulated immune response to infection. It is the number one cause of death in the Intensive Care Unit (ICU), accounting for 6 million casualties every year. Unfortunately, all clinical trials in the last decade failed due to the highly complex …

Sedentary behavior (SB) is prevalent in workplaces, putting office workers at an increased risk of severe health problems. To help designers and researchers gain a better understanding of office workers’ contextual concerns for physical inactivity (reducing SB and enhancing physical activity (PA)), we …

Abstract Purpose Knowledge of clinical pharmacotherapy is essential for all who prescribe medication. The aims of this study were to investigate differences in the pharmacotherapy and polypharmacy knowledge of medical and surgical residents and con sultants and whether this knowledge can be improved …

Sodium-glucose co-transporter 2 (SGLT2) inhibitors, including canagliflozin, reduce the risk of cardiovascular and kidney outcomes in patients with and without type 2 diabetes, albeit with a large interindividual variation. The underlying mechanisms for this variation in response might be attributed …

Per-fluoroalkyl and polyfluoroalkyl substances (PFASs) are persistent organic pollutants and do not degrade in the environment. They contain a carbon-fluorine bond, and these are called organic fluorides. A group of PFASs, which can be extracted from soil samples and be analysed, are called extractable …