Implementation of reliable methodologies allowing Reduction, Refinement, and Replacement (3Rs) of animal testing is a process that takes several decades and is still not complete. Reliable methods are essential for regulatory hazard assessment of chemicals where differences in test protocol can influence …

Background We aimed to identify healthcare needs, expectations, utilization, and the experienced treatment effects in a population of Dutch patients with hereditary spastic paraplegia (HSP). Methods We distributed an online questionnaire among 194 adult persons with HSP in the Netherlands, of which 166 …

The environmental conditions during the Tokyo Olympic and Paralympic Games are expected to be challenging, which increases the risk for participating athletes to develop heat-related illnesses and experience performance loss. To allow safe and optimal exercise performance of Dutch elite athletes, the …

This research provides an impact analysis for both facility manager and commercial real estate on the consequences and impact of crises on commercial real estate. Building blocks impact analysis and conceptual approach: The building blocks of the impact analysis must be: KPIs, risk assessment and change …

The concurrent growth of digital technologies, online shopping and spending power of millennials has created awareness and interest in environmental and socially conscious consumer behaviour. This research provides an evaluation and analysis of the website for the Ocean Bottle and the prospects of their …

At the age of a failing economic system and undeniable evidence of the effects humankind has had over the planet, it is necessary to look for alternatives to the way we live locally. This article explores the use of designing narratives and metanarratives to co-create imaginaries serving as the needed …

Purpose – As hospitals are now being designed with an increasing number of single rooms or cubicles, the individual preference of patients with respect to social contact is of great interest. The purpose of this study is to gain a better understanding of the experience of patients in an outpatient infusion …

Student satisfaction is the pinnacle upon which any effective online learning hinges. It is for that reason, educators design course activities that allow students to effectively practice, work together on relevant projects to personalize their learning. In emerging institutions like the Colleges of …

The aim of this study was to assess the current state of evidence and methodological quality of studies on implicit and explicit motor learning in both typically developing children and children with developmental disorders. A systematic literature review was conducted on the experimental literature …

This paper presents a generic trim problem formulation, in the form of a constrained optimization problem, which employs forces and moments due to the aircraft control surfaces as decision variables. The geometry of the Attainable Moment Set (AMS), i.e. the set of all control forces and moments attainable …