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DARTpaths, an in silico platform to investigate molecular mechanisms of compounds

Diksha Balla (Onderzoeker); Marvin Steijaert (Onderzoeker); Eefje Poppelaars (Onderzoeker); Marc Teunis (Onderzoeker); Monique van der Vloet (Onderzoeker); Marie Corradi (Onderzoeker); Elisabeth Dévière (Onderzoeker); Luuk Noothout (Onderzoeker); Wilco Tomassen (Onderzoeker); Martijn Rooseboom (Onderzoeker); Richard Currie (Onderzoeker); Cyrille Krul (Lector); Raymond Pieters (Lector); Vera van Noort (Onderzoeker); Marjolein Wildwater (Onderzoeker)

Summary: Xpaths is a collection of algorithms that allow for the prediction of compound-induced molecular mechanisms of action by integrating phenotypic endpoints of different species; and proposes follow-up tests for model organisms to validate these pathway predictions. The Xpaths algorithms are applied …

2023GezondheidArtikel

Salivary concentrations of secretory leukocyte protease inhibitor and matrix metallopeptidase-9 following a single bout of exercise are associated with intensity and hydration status

Karen Knipping (Onderzoeker); Shirley Kartaram (Onderzoeker); Marc Teunis (Onderzoeker); Nicolaas Zuithoff (Onderzoeker); Nicole Buurman (Onderzoeker); Laura M'Rabet (Onderzoeker); Klaske van Norren (Onderzoeker); Renger Witkamp (Onderzoeker); Raymond Pieters (Lector); Johan Garssen (Onderzoeker)

Aim: To investigate the effects of exercise on salivary concentrations of inflammatory markers by analyzing a panel of 25 inflammatory markers in subjects who had participated in bicycle ergometer tests varying in workload and hydration status. Methods: Fifteen healthy young men (20-35 years) had performed …

2023GezondheidArtikel

Optimization of an adverse outcome pathway network on chemical-induced cholestasis using an artificial intelligence-assisted data collection and confidence level quantification approach

Jonas van Ertvelde (Onderzoeker); Anouk Verhoeven (Onderzoeker); Amy Maerten (Onderzoeker); Axelle Cooreman (Onderzoeker); Bruna dos Santos Rodrigues (Onderzoeker); Julen Sanz-Serrano (Onderzoeker); Milos Mihajlovic (Onderzoeker); Ignacio Tripodi (Onderzoeker); Marc Teunis (Onderzoeker); Ramiro Jover (Onderzoeker); Thomas Luechtefeld (Onderzoeker); Tamara Vanhaecke (Onderzoeker); Jian Jang (Onderzoeker); Mathieu Vinken (Onderzoeker)

Background: Adverse outcome pathway (AOP) networks are versatile tools in toxicology and risk assessment that capture and visualize mechanisms driving toxicity originating from various data sources. They share a common structure consisting of a set of molecular initiating events and key events, connected …

2023GezondheidArtikel

Evidence for effect of l-serine, a novel therapy for GRIN2B-related neurodevelopmental disorder.

B. den Hollander; A.R.J. Veenvliet; Marieke Lindenschot; P. van Essen; G. Peters; A. Santos-Gómez; M. Olivella; X. Altafaj; M.M. Brands; B.A.W. Jacobs; C.D. van Karnebeek

RATIONALE: To date, causal therapy is potentially available for GRIN2B-related neurodevelopmental disorder (NDD) due to loss-of-function (LoF) variants in GRIN2B, resulting in dysfunction of the GluN2B subunit-containing N-methyl-d-aspartate receptor (NMDAR). Recently, in vitro experiments showed that …

2023AlgemeenArtikel

Perceive, Recall, Plan and Perform (PRPP)-Assessment Based on Parent-Provided Videos of Children with Mitochondrial Disorder: Action Design Research on Implementation Challenges.

Marieke Lindenschot; I.J.M. de Groot; M.W.G. Nijhuis -van der Sanden; Esther Steultjens; M.J.L. Graff; S. Koene

AIMS: Performing the Perceive, Recall, Plan and Perform (PRPP)-Assessment, using video material of everyday life, seems sensible to lower the patient burden, enhance ecological validity, and provide care at a distance. However, receipt of adequate video material is not self-evident and assessing videos …

2023AlgemeenArtikel

Development and validation of a test for measuring primary school students’ effective use of ICT: The ECC-ICT test

Pierre Gorissen; Marijke Kral; Gino Camp; Anne-Marieke van Loon; Kevin Ackermans

The growing emphasis on ICT in education has sparked significant interest and involvement from various stakeholders, including researchers, policymakers, and national and international enterprises. Together, they have contributed to developing ICT literacy frame-works to outline and scrutinise the essential …

2023Opvoeding & OnderwijsArtikel

Webinar Next life nieuwe kansen voor bestaande producten 2023-03-23

Vincent Wiegel (Lector)

27 deelnemers Hoe kunt u problemen met de toeleveringsketen overwinnen, afval verminderen en de levenscyclus van producten verlengen? Een productielijn met gereviseerde producten opzetten biedt in de tijd van schaarse grondstoffen en hoge energieprijzen kansen. Net als het onderhouden of de repareren …

2023TechniekAndersoortig materiaal

Workshop Opstarten Obeya 2023-11-16

Stef Tiggeloven (Onderzoeker)

18 deelnemers verzorgd door Tim Wiegel (Leading with Obeya) OVER DE WORKSHOP Trainer Tim Wiegel deelt in deze unieke interactieve Leading with Obeya (LWO) workshop strategieën waarmee deelnemers betere resultaten uit hun team halen en vorm en uitvoering geven aan de strategie. • Ervaring opdoen …

2023TechniekAndersoortig materiaal

The role of perceived contribution to the energy transition in acceptance of renewable energy sources

van Dijk, Mathilde (Life Sciences & Renewable Energy); Goedegebure, Robert; Nap, Jan Peter

2023AlgemeenConferentiebijdrage

Webinar Tools and their application for Product Modularity (EtO CtO) - 2023-10-05

Andras Ligeti (Onderzoeker)

Webinar Tools and their application for Product Modularity (EtO CtO) 5-10-2023 HLQC Webinar, in het kader van: Van EtO naar CtO, Andras Ligetti This webinar provides a comprehensive understanding of modular product design and its practical applications. We will delve into the world of modular product …

2023TechniekAndersoortig materiaal

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