BACKGROUND: Mobility is a key determinant and outcome of healthy ageing but its definition, conceptual framework and underlying constructs within the physical domain may need clarification for data comparison and sharing in ageing research. This study aimed to (1) review definitions and conceptual frameworks …

Aims Genetic hypertrophic cardiomyopathy (HCM) is caused by mutations in sarcomere protein-encoding genes (i.e. genotype-positive HCM). In an increasing number of patients, HCM occurs in the absence of a mutation (i.e. genotype-negative HCM). Mitochondrial dysfunction is thought to be a key driver of …

Skeletal muscle-related symptoms are common in both acute coronavirus disease (Covid)-19 and post-acute sequelae of Covid-19 (PASC). In this narrative review, we discuss cellular and molecular pathways that are affected and consider these in regard to skeletal muscle involvement in other conditions, …

CLEMENS APPRICH, DAPHNE DRAGONA, GEERT LOVINK, AND FLORIAN WÜST - CONVERSATION MODERATED BY KRISTOFFER GANSING On August 6, 2019, the curatorial advisors of the transmediale 2020 exhibition, ‘The Eternal Network’, gathered at the festival’s offices in Berlin for a conversation on the status of network …