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Effect of lung ultrasound-guided fluid deresuscitation on duration of ventilation in intensive care unit patients (CONFIDENCE)

Blok, Siebe G.; Mousa, Amne; Brouwer, Michelle G.; de Grooth, Harm-Jan; Neto, Ary Serpa; Blans, Michiel J.; den Boer, Sylvia; Dormans, Tom; Endeman, Henrik; Roeleveld, Timo; Scholten, Harm; van Slobbe-Bijlsma, Eline R.; Scholten, Erik; Touw, Hugo; van der Ven, Fleur Stefanie L. I. M.; Wils, Evert-Jan; van Westerloo, David J.; Heunks, Leo M. A.; Schultz, Marcus J.; Paulus, Frederique (Lectoraat Critical Care); Tuinman, Pieter R.

Background Fluid therapy is a common intervention in critically ill patients. It is increasingly recognised that deresuscitation is an essential part of fluid therapy and delayed deresuscitation is associated with longer invasive ventilation and length of intensive care unit (ICU) stay. However, optimal …

2023AlgemeenArtikel

Studying Telmisartan Plasma Exposure, Kidney Distribution, Receptor Occupancy, and Response in Patients With Type 2 Diabetes Using [11C]Telmisartan

van der Hoek, Sjoukje; Mulder, Douwe J.; T.M. Willemsen, Antoon; Visser, Ton J.; Heeres, André (Biobased Chemistry & Refinery); Slart, Riemer H.J.A.; Elsinga, Philip H.; Heerspink, Hiddo J. L.; Stevens, Jasper

The angiotensin receptor blocker telmisartan slows progression of kidney disease in patients with type 2 diabetes (T2D), yet many patients remain at high risk for progressive kidney function loss. The underlying mechanisms for this response variation might be attributed to differences in angiotensin-1 …

2022-09-07AlgemeenArtikel

Association of early positive end-expiratory pressure settings with ventilator-free days in patients with coronavirus disease 2019 acute respiratory distress syndrome

BACKGROUND : There is uncertainty about how much positive end-expiratory pressure (PEEP) should be used in patients with acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19). OBJECTIVE : To investigate whether a higher PEEP strategy is superior to a lower PEEP strategy …

2021-12AlgemeenArtikel

Bundled care in acute kidney injury in critically ill patients, a before-after educational intervention study

Koeze, Jacqueline; van der Horst, Iwan C C; Wiersema, Renske; Keus, Frederik; Cox, Eline G M; Zijlstra, Jan G; van Meurs, Matijs; Dieperink, Willem

BACKGROUND: Acute kidney injury (AKI) often occurs in critically ill patients. AKI is associated with mortality and morbidity. Interventions focusing on the reduction of AKI are suggested by the Kidney Disease: Improving Global Outcomes guideline. We hypothesized that these educational interventions …

2020-09-03AlgemeenArtikel

Magnesium prevents vascular calcification in Klotho deficiency

Alkema, Wynand (Data Science For Life Science & Health)

Klotho knock-out mice are an important model for vascular calcification, which is associated with chronic kidney disease. In chronic kidney disease, serum magnesium inversely correlates with vascular calcification. Here we determine the effects of serum magnesium on aortic calcification in Klotho knock-out …

2020-03-01AlgemeenArtikel

The influence of clinical variables on the risk of developing chronic conditions in ICU survivors

van Beusekom, Ilse; Bakhshi-Raiez, Ferishta; van der Schaaf, Marike (Faculteit Gezondheid); Dongelmans, Dave A; Busschers, Wim B; de Keizer, Nicolette F

PURPOSE: To assess the association of clinical variables and the development of specified chronic conditions in ICU survivors. MATERIALS AND METHODS: A retrospective cohort study, combining a national health insurance claims database and a national quality registry for ICUs. Claims data from 2012 to …

2020-02-01AlgemeenArtikel

A nurse-led self-management support intervention (ZENN) for kidney transplant recipients using intervention mapping: protocol for a mixed-methods feasibility study

D. Beck; J.M.J. Been-Dahmen (Onderzoeker); M.A.C. Peeters; J.W. Grijpma; H.A. van der Stege; M. Tielen; Marleen van Buren; W. Weimar; E. Ista; E.K. Massey; A.L. van Staa (Lector)

Background: Optimal self-management in kidney transplant recipients is essential for patient and graft survival, reducing comorbidity and health care costs while improving the quality of life. However, there are few effective interventions aimed at providing self-management support after kidney transplantation. Objective: …

2019-03-01GezondheidArtikel

Physical activity, sedentary time, and associated factors in recipients of solid-organ transplantation

van Adrichem, Edwin J.; Dekker, Rienk; Krijnen, Wim P (Statistical Techniques For Applied Research); Verschuuren, Erik A M; Dijkstra, Pieter U.; van der Schans, Cees P (Healthy Ageing, Allied Health Care And Nursing)

Background: Short-term survival after solid-organ transplantation has substantially improved, and the focus has shifted to long-term survival, including the role of physical activity (PA). Knowledge about PA and sedentary time in recipients of solid-organ transplantation is limited, and identification …

2018-08-01AlgemeenArtikel

Hypertension and Frailty Syndrome in Old Age

Robbert Gobbens (Lector)

Abstract: Hypertension is both a health problem and a financial one globally. It affects nearly 30 % of the general population. Elderly people, aged ≥65 years, are a special group of hypertensive patients. In this group, the overall prevalence of the disease reaches 60 %, rising to 70 % in those aged …

2017GezondheidArtikel

Hallmarks of nutritional status in kidney transplant recipients

ter Beek, Lies; Gomes Neto, Antonio; Eisenga, Michele; Roodenburg, Jan; van der Schans, Cees P. (Healthy Ageing, Allied Health Care And Nursing); Ottery, Faith D.; Bakker, Stephan; Jager, Harriët (Healthy Ageing, Allied Health Care And Nursing)

2016-09-19AlgemeenConferentiebijdrage

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