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A proteomics approach to identify COPD-related changes in lung fibroblasts

Bekker, Nicolaas J.; van Pijkeren, Alienke; Wolters, Justina C.; Sánchez Brotons, Alejandro; Guryev, Victor; Woldhuis, Roy R.; Bischoff, Rainer; Alkema, Wynand (Data Science For Life Science & Health); Horvatovich, Peter; van Nijnatten, Johannes L.L.; van den Berge, Maarten; Timens, Wim; Brandsma, Corry-Anke

Background: Lung fibroblasts are implicated in abnormal tissue repair in chronic obstructive pulmonary disease (COPD). The exact mechanisms are unknown and comprehensive analysis comparing COPD- and control fibroblasts is lacking. Aim: To gain insight in the role of lung fibroblasts in COPD pathology …

2023-04-01AlgemeenArtikel

Enterocytes, fibroblasts and myeloid cells synergize in anti-bacterial and anti-viral pathways with IL22 as the central cytokine

Jean Paul ten Klooster (Onderzoeker); Marianne Bol-Schoenmakers (Onderzoeker); Kitty van Summeren (Onderzoeker); Arno van Vliet (Onderzoeker); Cornelis de Haan (Onderzoeker); Frank van Kuppeveld (Onderzoeker); Saertje Verkoeijen (Onderzoeker); Raymond Pieters (Lector)

IL22 is an important cytokine involved in the intestinal defense mechanisms against microbiome. By using ileum-derived organoids, we show that the expression of anti-microbial peptides (AMPs) and anti-viral peptides (AVPs) can be induced by IL22. In addition, we identified a bacterial and a viral route, …

2021GezondheidArtikel

Wat is het effect van de niet- ablatieve fractionele laser op huidveroudering?

José Boekelmans; Thérèse Rietveld

Probleemstelling Het Rijksinstituut voor Volksgezondheid en Milieu signaleert een toenemend gebruik van fractionele lasers voor cosmetische doeleinden waaronder rimpelreductie. Een onderzoek naar de effectiviteit van de niet- ablatieve fractionele laser voor huidveroudering is van belang omdat binnen …

2013GezondheidBachelor

Quantitation of urokinase antigen in plasma and culture media by use of an ELISA

Binnema, D J; van Iersel, J J; Dooijewaard, G

An ELISA was set up using polyvinylchloride microtiter plates coated with rabbit anti-UK IgG's and affino-purified goat anti-UK IgG's as second antibody. Detection occurred with rabbit anti-goat IgG antibodies conjugated with alkaline phosphatase. The assay is specific for urokinase (UK) with a detection …

1986-09-01AlgemeenArtikel

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A proteomics approach to identify COPD-related changes in lung fibroblasts

Enterocytes, fibroblasts and myeloid cells synergize in anti-bacterial and anti-viral pathways with IL22 as the central cytokine

Wat is het effect van de niet- ablatieve fractionele laser op huidveroudering?

Quantitation of urokinase antigen in plasma and culture media by use of an ELISA

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