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Pitch over Fit4cirrhotics@home op het Nationaal Prehabilitatie Congres

Talen, Daniëlle

Presentatie over het studieprotocol van het fit4cirrhotics@home onderzoek. 1 van de 5 beste inzendingen.

2024-09-19Mens & MaatschappijConferentiebijdrage

The application of natural language processing for the extraction of mechanistic information in toxicology

Marie Corradi (Onderzoeker); Thomas Luechtefeld (Onderzoeker); Alyanne de Haan (Onderzoeker); Raymond Pieters (Lector); Jonathan Freedman (Onderzoeker); Tamara Vanhaecke (Onderzoeker); Mathieu Vinken (Onderzoeker); Marc Teunis (Onderzoeker)

To study the ways in which compounds can induce adverse effects, toxicologists have been constructing Adverse Outcome Pathways (AOPs). An AOP can be considered as a pragmatic tool to capture and visualize mechanisms underlying different types of toxicity inflicted by any kind of stressor, and describes …

2024GezondheidArtikel

Obesity-induced TET2 disfunction in DNMT3A mutated haematopoietic cells increases myelopoiesis, resulting in increased risk for cardiovascular disease development

Arina Kochetkova (Student)

Clonal haematopoiesis of intermediate potential (CHIP) driven by somatic mutations in DNMT3A and TET2 has been recently recognized as a new risk factor for cardiovascular diseases (CVD). The haematopoietic clones with mutations in these genes are frequently found in myeloid malignancies and according …

2023-06-13Gezondheid; …Bachelor

In vitro–in silico-based prediction of inter-individual and inter-ethnic variations in the dose-dependent cardiotoxicity of R- and S-methadone in humans

Shi, M.; Dong, Y.; Bouwmeester, H.; Rietjens, I.M.C.M.; Strikwold, M. (Lector)

New approach methodologies predicting human cardiotoxicity are of interest to support or even replace in vivo-based drug safety testing. The present study presents an in vitro–in silico approach to predict the effect of inter-individual and inter-ethnic kinetic variations in the cardiotoxicity of R- …

2022-05-23GezondheidArtikel

Inter-individual variation in chlorpyrifos toxicokinetics characterized by physiologically based kinetic (PBK) and Monte Carlo simulation comparing human liver microsome and Supersome™ cytochromes P450 (CYP)-specific kinetic data as model input

Zhao, S.; Wesseling, S.; Rietjens, I.M.C.M.; Strikwold, M. (Lector)

The present study compares two approaches to evaluate the effects of inter-individual differences in the biotransformation of chlorpyrifos (CPF) on the sensitivity towards in vivo red blood cell (RBC) acetylcholinesterase (AChE) inhibition and to calculate a chemical-specific adjustment factor (CSAF) …

2022-03-16GezondheidArtikel

Intra-abdominal hypertension and abdominal compartment syndrome in patients admitted to the ICU

Smit, Marije; Koopman, Bart; Hulscher, Jan B F; Hofker, H Sijbrand; van Meurs, Matijs; Zijlstra, Jan G; Dieperink, Willem

BACKGROUND: Intra-abdominal hypertension is frequently present in critically ill patients and is an independent predictor for mortality. Risk factors for intra-abdominal hypertension and abdominal compartment syndrome have been widely investigated. However, data are lacking on prevalence and outcome …

2020-10-01AlgemeenArtikel

Obese older Type 2 Diabetes Mellitus patients with muscle insulin resistance benefit from an enriched protein drink during combined lifestyle intervention

Pasman, Wilrike J.; Memelink, Robert G. (Centre Of Expertise Urban Vitality); de Vogel-Van den Bosch, Johan; Begieneman, Mark P.V.; van den Brink, Willem J.; Weijs, Peter J.M. (Centre Of Expertise Urban Vitality); Wopereis, Suzan

(1) Background: Recent research showed that subtypes of patients with type 2 diabetes may differ in response to lifestyle interventions based on their organ-specific insulin resistance (IR). (2) Methods: 123 Subjects with type 2 diabetes were randomized into 13-week lifestyle intervention, receiving …

2020-09-29AlgemeenArtikel

Health problems and care needs in patients with Korsakoff’s syndrome

Mirjam Johanna van Dam; B.K.G. (Berno) van Meijel (Lector); A. Postma; Erik Oudman

ABSTRACT: Introduction: The literature shows that Korsakoff’s syndrome is associated with a wide range of severe comorbid somatic and psychiatric health problems that lead to care needs in several domains of functioning. Aim: To provide a comprehensive overview of Korsakoff patients’ health conditions …

2019-12-26GezondheidArtikel

Integrating physiologically based kinetic (PBK) and Monte Carlo modelling to predict inter-individual and inter-ethnic variation in bioactivation and liver toxicity of lasiocarpine

Ning, J.; Rietjens, I.M.C.M.; Strikwold, M. (Lector)

The aim of the present study was to predict the effect of inter-individual and inter-ethnic human kinetic variation on the sensitivity towards acute liver toxicity of lasiocarpine in the Chinese and the Caucasian population, and to derive chemical specific adjustment factors (CSAFs) by integrating variation …

2019-09-11GezondheidArtikel

Use of an in vitro–in silico testing strategy to predict inter-species and inter-ethnic human differences in liver toxicity of the pyrrolizidine alkaloids lasiocarpine and riddelliine

Ning, J.; Chen, L.; Strikwold, M. (Lector)

Lasiocarpine and riddelliine are pyrrolizidine alkaloids (PAs) known to cause liver toxicity. The aim of this study was to predict the inter-species and inter-ethnic human differences in acute liver toxicity of lasiocarpine and riddelliine using physiologically based kinetic (PBK) modelling based reverse …

2019-01-19GezondheidArtikel

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