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GMP Compliant Synthesis of Canagliflozin, a Novel PET Tracer for the Sodium−Glucose Cotransporter 2

Heeres, André (Biobased Chemistry & Refinery); van der Hoek, Sjoukje; Antunes, Inês F.; Attia, Khaled A.; Jacquet, Olivier; Bulthuis, Marian; Zijlma, Rolf; Boersma, Hendrikus H.; van Goor, Harry; Visser, Ton J.; Heerspink, Hiddo J. L.; Elsinga, Philip H.; Stevens, Jasper

Inhibition of the sodium−glucose cotransporter 2 (SGLT2) by canagliflozin in type 2 diabetes mellitus results in large between-patient variability in clinical response. To better understand this variability, the positron emission tomography (PET) tracer [18F]canagliflozin was developed via a Cu-mediated …

2021-11-08AlgemeenArtikel

GMP Compliant Synthesis of [18F]Canagliflozin, a Novel PET Tracer for the Sodium−Glucose Cotransporter 2

van der Hoek, Sjoukje; Antunes, Inês F.; Attia, Khaled A.; Jacquet, Olivier; Heeres, André (Biobased Chemistry & Refinery); Bulthuis, Marian; Zijlma, Rolf; Boersma, Hendrikus H.; van Goor, Harry; Visser, Ton J.; Heerspink, Hiddo J. L.; Elsinga, Philip H.; Stevens, Jasper

Inhibition of the sodium–glucose cotransporter 2 (SGLT2) by canagliflozin in type 2 diabetes mellitus results in large between-patient variability in clinical response. To better understand this variability, the positron emission tomography (PET) tracer [18F]canagliflozin was developed via a Cu-mediated …

2021-11-08AlgemeenArtikel

Isomalto/malto-polysaccharide, a novel soluble dietary fiber made via enzymatic conversion of starch

Leemhuis, Hans; Dobruchowska, Justyna M.; Ebbelaar, Monique; Faber, Folkert (Life Sciences & Renewable Energy); Buwalda, Pieter L.; van der Maarel, Marc J. E. C.; Kamerling, Johannis P.; Dijkhuizen, Lubbert

Dietary fibers are at the forefront of nutritional research because they positively contribute to human health. Much of our processed foods contain, however, only small quantities of dietary fiber, because their addition often negatively affects the taste, texture, and mouth feel. There is thus an urge …

2014-11-20AlgemeenArtikel

Orthogonal self-assembly of low molecular weight hydrogelators and surfactants

Heeres, Andre (Biobased Ingredients And Materials); van, der Pol Cornelia; Stuart, Marc; Friggeri, Arianna; Feringa, Ben L.; van, Esch Jan

The concurrent self-assembly of new 1,3,5-trisamide-cyclohexane-based low molecular weight hydrogelators and various surfactants in water leads to the formation of self-assembled fibrillar networks with encapsulated micelles. This prototype system presents an example of orthogonal self-assembly, that …

2003-11-26AlgemeenArtikel

Catalytic enantioselective annulations via 1,4-addition - Aldol cyclization of functionalized organozinc reagents [9]

Naasz, Robert; Arnold, Leggy A.; Pineschi, Mauro; Keller, Erik (Biorefinery); Feringa, Ben L.

1999-01-26AlgemeenArtikel

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GMP Compliant Synthesis of Canagliflozin, a Novel PET Tracer for the Sodium−Glucose Cotransporter 2

GMP Compliant Synthesis of [18F]Canagliflozin, a Novel PET Tracer for the Sodium−Glucose Cotransporter 2

Isomalto/malto-polysaccharide, a novel soluble dietary fiber made via enzymatic conversion of starch

Orthogonal self-assembly of low molecular weight hydrogelators and surfactants

Catalytic enantioselective annulations via 1,4-addition - Aldol cyclization of functionalized organozinc reagents [9]

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