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Effect of mechanical power on mortality in invasively ventilated ICU patients without the acute respiratory distress syndrome

van Meenen, David M.P.; Algera, Anna Geke; Schuijt, Michiel T.U.; Simonis, Fabienne D.; van der Hoeven, Sophia M.; Neto, Ary Serpa; Abreu, Marcelo Gama de; Pelosi, Paolo; Paulus, Frederique (Lectoraat Critical Care); Schultz, Marcus J.

BACKGROUND The mechanical power of ventilation (MP) has an association with outcome in invasively ventilated patients with the acute respiratory distress syndrome (ARDS). Whether a similar association exists in invasively ventilated patients without ARDS is less certain. OBJECTIVE To investigate the …

2023-01AlgemeenArtikel

Effect of lung ultrasound-guided fluid deresuscitation on duration of ventilation in intensive care unit patients (CONFIDENCE)

Blok, Siebe G.; Mousa, Amne; Brouwer, Michelle G.; de Grooth, Harm-Jan; Neto, Ary Serpa; Blans, Michiel J.; den Boer, Sylvia; Dormans, Tom; Endeman, Henrik; Roeleveld, Timo; Scholten, Harm; van Slobbe-Bijlsma, Eline R.; Scholten, Erik; Touw, Hugo; van der Ven, Fleur Stefanie L. I. M.; Wils, Evert-Jan; van Westerloo, David J.; Heunks, Leo M. A.; Schultz, Marcus J.; Paulus, Frederique (Lectoraat Critical Care); Tuinman, Pieter R.

Background Fluid therapy is a common intervention in critically ill patients. It is increasingly recognised that deresuscitation is an essential part of fluid therapy and delayed deresuscitation is associated with longer invasive ventilation and length of intensive care unit (ICU) stay. However, optimal …

2023AlgemeenArtikel

Mortality associated with early changes in ARDS severity in COVID-19 patients - Insights from the PRoVENT-COVID study

Schuijt, Michiel T.U.; Martin-Loeches, Ignacio; Schultz, Marcus J.; Paulus, Frederique (Lectoraat Critical Care); Neto, Ary Serpa; Stilma, W. (Faculteit Gezondheid)

PURPOSE: We investigated changes in ARDS severity and associations with outcome in COVID-19 ARDS patients. METHODS: We compared outcomes in patients with ARDS classified as 'mild', 'moderate' or 'severe' at calendar day 1, and after reclassification at calendar day 2. The primary endpoint was 28-day …

2021-10AlgemeenArtikel

Practice of adjunctive treatments in critically ill COVID-19 patients-rational for the multicenter observational PRoAcT-COVID study in The Netherlands

Valk, Christel M. A.; Swart, Pien; Boers, Leonoor S.; Botta, Michela; Bos, Lieuwe D. J,; de Abreu, Marcelo Gama; Hol, Liselotte; Hollmann, Markus W.; Horn, Janneke; Martin-Loeches, Ignacio; Mazzinari, Guido; Myatra, Sheila N.; Nijbroek, Sunny G.; Rosenberg, Neeltje M.; Stilma, Willemke (Faculteit Gezondheid); Tsonas, Anissa M.; van der Ven, Ward H.; Neto, Ary Serpa; Schultz, Marcus J.; Paulus, Frederique

Background: Patients with coronavirus disease 2019 (COVID-19) may need hospitalization for supplemental oxygen, and some need intensive care unit (ICU) admission for escalation of care. Practice of adjunctive and supportive treatments remain uncertain and may vary widely between countries, within countries …

2021-05AlgemeenArtikel

Dead space estimates may not be independently associated with 28-day mortality in COVID-19 ARDS

Morales-Quinteros, Luis; Neto, Ary Serpa; Artigas, Antonio; Blanch, Lluis; Botta, Michela; Kaufman, David A.; Schultz, Marcus J.; Tsonas, Anissa M.; Paulus, Frederique; Bos, Lieuwe D.

BACKGROUND: Estimates for dead space ventilation have been shown to be independently associated with an increased risk of mortality in the acute respiratory distress syndrome and small case series of COVID-19-related ARDS. METHODS: Secondary analysis from the PRoVENT-COVID study. The PRoVENT-COVID is …

2021AlgemeenArtikel

PRactice of VENTilation in Patients with Novel Coronavirus Disease (PRoVENT-COVID)

Boers, Noor S.; Botta, Michela; Tsonas, Annisa M.; Algera, Anna Geke; Pillay, Janesh; Dongelmans, Dave A.; Horn, Janneke; Vlaar, Alexander P. J.; Hollmann, Markus W.; Bos, Lieuwe D. J.; Paulus, Frederique (Lectoraat Critical Care); Neto, Ary Serpa; Schultz, Marcus J.

Background: The coronavirus disease 2019 (COVID-19) pandemic is rapidly expanding across the world, with more than 100,000 new cases each day as of end-June 2020. Healthcare workers are struggling to provide the best care for COVID-19 patients. Approaches for invasive ventilation vary widely between …

2020-10AlgemeenArtikel

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