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Enterocytes, fibroblasts and myeloid cells synergize in anti-bacterial and anti-viral pathways with IL22 as the central cytokine

Jean Paul ten Klooster (Onderzoeker); Marianne Bol-Schoenmakers (Onderzoeker); Kitty van Summeren (Onderzoeker); Arno van Vliet (Onderzoeker); Cornelis de Haan (Onderzoeker); Frank van Kuppeveld (Onderzoeker); Saertje Verkoeijen (Onderzoeker); Raymond Pieters (Lector)

IL22 is an important cytokine involved in the intestinal defense mechanisms against microbiome. By using ileum-derived organoids, we show that the expression of anti-microbial peptides (AMPs) and anti-viral peptides (AVPs) can be induced by IL22. In addition, we identified a bacterial and a viral route, …

2021GezondheidArtikel

Dietary Supplementation with Nondigestible Oligosaccharides Reduces Allergic Symptoms and Supports Low Dose Oral Immunotherapy in a Peanut Allergy Mouse Model

Laura Wagenaar (Onderzoeker); Marianne Bol-Schoenmakers (Onderzoeker); Giulio Giustarini (Onderzoeker); Marlotte M. Vonk (Onderzoeker); Betty C.A.M. van Esch (Onderzoeker); Léon M.J. Knippels (Onderzoeker); Johan Garssen (Onderzoeker); Joost Smit (Onderzoeker); Raymond Pieters (Lector)

Abstract 1 Scope A major downside of oral immunotherapy (OIT) for food allergy is the risk of severe side effects. Non‐digestible short‐ and long‐chain fructo‐oligosaccharides (scFOS/lcFOS) reduce allergy development in murine models. Therefore, it is hypothesized that scFOS/lcFOS can also support …

2018-08-13GezondheidArtikel

Indole-3-carbinol, a plant nutrient and AhR-Ligand precursor, supports oral tolerance against OVA and improves peanut allergy symptoms in mice

Christiane Hammerschmidt-Kamper (Onderzoeker); Daniel Biljes (Onderzoeker); Katja Merches (Onderzoeker); Irina Steiner (Onderzoeker); Daldrup Thomas (Onderzoeker); Marianne Bol-Schoenmakers (Onderzoeker); Raymond Pieters (Lector); Charlotte Esser (Onderzoeker)

From PLoS website: In general, dietary antigens are tolerated by the gut associated immune system. Impairment of this so-called oral tolerance is a serious health risk. We have previously shown that activation of the ligand-dependent transcription factor aryl hydrocarbon receptor (AhR) by the environmental …

2017GezondheidArtikel

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Enterocytes, fibroblasts and myeloid cells synergize in anti-bacterial and anti-viral pathways with IL22 as the central cytokine

Dietary Supplementation with Nondigestible Oligosaccharides Reduces Allergic Symptoms and Supports Low Dose Oral Immunotherapy in a Peanut Allergy Mouse Model

Indole-3-carbinol, a plant nutrient and AhR-Ligand precursor, supports oral tolerance against OVA and improves peanut allergy symptoms in mice

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