Objective: The aim of this study was to investigate age group, gender, and baseline depressive symptom severity as possible effect moderators in (1) cognitive versus behavioral based CBT-modules and (2) sequences of modules that started either with cognitive or behavioral modules in indicated depression …

Background: Lung fibroblasts are implicated in abnormal tissue repair in chronic obstructive pulmonary disease (COPD). The exact mechanisms are unknown and comprehensive analysis comparing COPD- and control fibroblasts is lacking. Aim: To gain insight in the role of lung fibroblasts in COPD pathology …

Background: In hospitalized patients with COVID-19, the dosing and timing of corticosteroids vary widely. Low-dose dexamethasone therapy reduces mortality in patients requiring respiratory support, but it remains unclear how to treat patients when this therapy fails. In critically ill patients, high-dose …

Abstract Background: People with severe mental illness (SMI) often suffer from long-lasting symptoms that negatively influence their social functioning, their ability to live a meaningful life, and participation in society. Interventions aimed at increasing physical activity can improve social functioning, …

Novieten leren nieuwe probleem-oplostaken op een effectieve manier door het bestuderen van voorbeelden, zoals stap-voor-stap uitgeschreven oplossingsprocedures of een docent die (op video) voordoet en uitlegt hoe je een probleem oplost. Steeds vaker worden (video)voorbeelden en oefenproblemen ingezet …

The quantification and identification of new plasmid-acquiring bacteria in representative mating conditions is critical to characterize the risk of horizontal gene transfer in the environment. This study aimed to quantify conjugation events resulting from manure application to soils and identify the …

Rationale: While combined lifestyle interventions have multiple health benefits, their impact on the oral microbiome is not known. We explored the effects of a lifestyle intervention including protein drink on the oral microbiome in older adults with obesity and type 2 diabetes (T2D). Methods: In a post-hoc …

Problem-solving tasks form an important part of (higher education) curricula, especially in STEM-domains. For learners with little or no prior knowledge (novices), an effective way to learn new problem-solving tasks is by studying examples. These can be written out step-by-step solution procedures of …

Application of animal manure to soils results in the introduction of manure-derived bacteria and their antimicrobial resistance genes (ARGs) into soils. ResCap is a novel targeted-metagenomic approach that allows the detection of minority components of the resistome gene pool without the cost-prohibitive …

In 2001 and 2002 an excavation conducted in the town of Alphen aan den Rijn in the Netherlands revealed the vestiges of a Roman fort, Castellum Albaniana, situated along the historical Rhine delta and used for centuries during the Roman occupation (41 AD − 275 CE). Among the animal bones retrieved from …