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Screening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation

Heeres, André (Biobased Ingredients And Materials); Xu, Hu; van Marion, Denise MS; Hoogstra-Berends, Femke; Zhang, Deli; Seerden, Jean-Paul; Loen, Lizette; Steen, Herman; Henning, Robert H; Brundel, Bianca J J M

Background: The heat shock protein (HSP) inducer, geranylgeranylacetone (GGA), was previously found to protect against atrial fibrillation (AF) remodeling in experimental model systems. Clinical application of GGA in AF is limited, due to low systemic concentrations owing to the hydrophobic character …

2019-01-18AlgemeenArtikel

Heat shock protein-inducing compounds as therapeutics to restore proteostasis in atrial fibrillation

Hoogstra-Berends, Femke; Meijering, Roelien A M; Zhang, Deli; Heeres, André (Biobased Ingredients And Materials); Loen, Lizette; Seerden, Jean-Paul; Kuipers, Irma; Kampinga, Harm H; Henning, Robert H; Brundel, Bianca J J M

Atrial fibrillation (AF) is the most common clinical tachyarrhythmia associated with significant morbidity and mortality and is expected to affect approximately 30 million North Americans and Europeans by 2050. AF is a persistent disease, caused by progressive, often age-related, derailment of proteostasis …

2012-04-01AlgemeenArtikel

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Screening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation

Heat shock protein-inducing compounds as therapeutics to restore proteostasis in atrial fibrillation

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