Alzheimer's disease (AD) is the common neurodegenerative disorder and the most frequent cause of dementia. The disease accounts around 80% of all dementia diagnoses. The main reason of developing AD is amyloid cascade which starts from missense mutations in APP (amyloid precursor protein), Rho-associated …

The upscaling of biphasic photochemical reactions is challenging because of the inherent constraints of liquid-gas mixing and light penetration. Using semi-permeable coaxial flow chemistry within a modular photoreactor, the photooxidation of the platform chemical furfural was scaled up to produce routinely …

Inhibition of the sodium–glucose cotransporter 2 (SGLT2) by canagliflozin in type 2 diabetes mellitus results in large between-patient variability in clinical response. To better understand this variability, the positron emission tomography (PET) tracer [18F]canagliflozin was developed via a Cu-mediated …

Inhibition of the sodium−glucose cotransporter 2 (SGLT2) by canagliflozin in type 2 diabetes mellitus results in large between-patient variability in clinical response. To better understand this variability, the positron emission tomography (PET) tracer [18F]canagliflozin was developed via a Cu-mediated …

Conceptual mathematical models play a crucial role in the development of engineering specifications required in the detailed design process and in the test and evaluation of avionics equipment. Specifying aircraft proximity is a precursor to the development of aircraft Detect and Avoid (DAA) systems …

In his latest book, Recursivity and Contingency (2019), the Hong Kong philosopher Yuk Hui argues that recursivity is not merely mechanical repetition. He is interested in “irregularity deviating from rules.” He develops what could be called a neovitalist position, which goes beyond the view, dominant …

Perfluoro alkyl substances (PFAS) are substances in which contain multiple fluorine atoms. The fluorine atoms are bound to, often, long carbon chains. PFAS are able to repel dirt and water, due to the large amount of fluorine atoms in the molecules. PFAS are also chemically and thermally stable. Many …

In the search for low greenhouse gas propulsion, the dual fuel engine provides a solution to use low carbon fuel at diesel-like high efficiency. Also a lower emission of NOx and particles can be achieved by replacing a substantial part of the diesel fuel by for example natural gas. Limitations can be …

From the thesis: "Summary Metabolic diseases that are characterized by a disturbance in energy balance because of feeding behavior, such as obesity and anorexia are known to be a world-wide problem. A better understanding in central regulation of energy intake and metabolism could give more insight in …

Coronary heart disease is the most occurring type of cardiovascular disease. It caused 7.22 million deaths in 2002 and its prevalence is estimated to keep on increasing. Everyday diet was shown to be of influence and added sugar was linked with adverse health condition. It could therefore be a precursor …