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Obesity-induced TET2 disfunction in DNMT3A mutated haematopoietic cells increases myelopoiesis, resulting in increased risk for cardiovascular disease development

Arina Kochetkova (Student)

Clonal haematopoiesis of intermediate potential (CHIP) driven by somatic mutations in DNMT3A and TET2 has been recently recognized as a new risk factor for cardiovascular diseases (CVD). The haematopoietic clones with mutations in these genes are frequently found in myeloid malignancies and according …

2023-06-13Gezondheid; …Bachelor

Enterocytes, fibroblasts and myeloid cells synergize in anti-bacterial and anti-viral pathways with IL22 as the central cytokine

Jean Paul ten Klooster (Onderzoeker); Marianne Bol-Schoenmakers (Onderzoeker); Kitty van Summeren (Onderzoeker); Arno van Vliet (Onderzoeker); Cornelis de Haan (Onderzoeker); Frank van Kuppeveld (Onderzoeker); Saertje Verkoeijen (Onderzoeker); Raymond Pieters (Lector)

IL22 is an important cytokine involved in the intestinal defense mechanisms against microbiome. By using ileum-derived organoids, we show that the expression of anti-microbial peptides (AMPs) and anti-viral peptides (AVPs) can be induced by IL22. In addition, we identified a bacterial and a viral route, …

2021GezondheidArtikel

Preliminary results of a pilot study using validated nutrition screening tools to investigate the nutrition evolution of patients with Acute Myeloid Leukemia

Heimgartner, Joy; Vruwink, Joan; Hogan, William; Carlson, Stacey; MacMahon, Molly; Girgen, Kayla; Johnson, Kourtney; Riley, Anna; Jager-Wittenaar, Harriët (Malnutrition And Healthy Ageing); Ottery, Faith D.

2018AlgemeenConferentiebijdrage

Preliminary results of a pilot study using validated nutrition screening tools to investigate the nutrition evolution of patients with Acute Myeloid Leukemia

Heimgartner, Joy; Vruwink, Joan; Hogan, William; MacMahon, Molly; Butterbrodt, Alex; Diedrich, Carlissa; Kunde, Molly; Spencer, Kristi; Jager-Wittenaar, Harriët (Malnutrition And Healthy Ageing); Ottery, Faith D.

2017AlgemeenConferentiebijdrage

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Obesity-induced TET2 disfunction in DNMT3A mutated haematopoietic cells increases myelopoiesis, resulting in increased risk for cardiovascular disease development

Enterocytes, fibroblasts and myeloid cells synergize in anti-bacterial and anti-viral pathways with IL22 as the central cytokine

Preliminary results of a pilot study using validated nutrition screening tools to investigate the nutrition evolution of patients with Acute Myeloid Leukemia

Preliminary results of a pilot study using validated nutrition screening tools to investigate the nutrition evolution of patients with Acute Myeloid Leukemia

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