Alzheimer's disease is a complex neurodegenerative disease and the most prevalent form of dementia. It affects every 14th person after the age of 65, thus making it a serious concern in modern society. Furthermore, currently available treatment is restricted only to symptomatic and is not highly effective. …

Autism Spectrum Disorder (ASD) is a neurobiological condition affecting about 1% of the population, characterized by repetitive behaviors, restricted interests, and communication deficiencies. While ASD has both genetic and environmental influences, the role heritable yet non genetic gastrointestinal …

Over time memories are believed to undergo a time-dependent reorganization in the brain through a process known as systems consolidation during which they become less dependent on the hippocampus and more dependent on the neocortical structures. This reorganization is accompanied by a generalization …

Tumor necrosis factor alpha (TNF-α) and its key role in modulating immune responses has been widely recognized as a therapeutic target for inflammatory and neurodegenerative diseases. Even though inhibition of TNF-α is beneficial for the treatment of certain inflammatory diseases, total neutralization …

Background and objectives Before the Covid-19 pandemic, important social studies already indicated the severe negative feedback associated with high-rise developments. During the Covid-19 pandemic, citizens were confronted with their neighbourhoods’ insufficient restorative capacity to maintain their …

The coronavirus pandemic highlighted the vital role urban areas play in supporting citizens’ health and well-being (Ribeiro et al., 2021). In times of (personal) vulnerability, citizens depend on their neighbourhood for performing daily physical activities to restore their mental state, but public spaces …

This graduation project was conducted for Thales Nederland B.V., Hengelo. The primary goal of this graduation assignment was to explore and research whether or not gaming devices could be used to increase usability while performing various combat operations within TACTICOS (a Combat Management System …

People in western countries spend approximately 90% of their time indoors. This severely affects their health (WHO 2013; Klepeis et al. 2001). The health risks are exacerbated if people travel between indoor spaces by car or public transport. Buildings on streets specifically designed to create a human …

It is estimated that over 30,000 lesions in the DNA are generated per cell per day. In S-phase, lesions in the DNA can stall replication, which can lead to secondary lesions such as DNA double- strand breaks. The DNA damage tolerance (DDT) network enables replication to be continued in the presence of …

As the revolutions across the Arab world that came to a head in 2011 devolved into civil war and military coup, representation and history acquired a renewed and contested urgency. The capacities of the internet have enabled sharing and archiving in an unprecedented fashion. Yet, at the same time, these …