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Zocht je misschien: radiotherapie?

The impact of anatomical changes during photon or proton based radiation treatment on tumor dose in glioblastoma dose escalation trials

Eline Hessen; Sebastian Makocki; Uulke A. van der Heide; Bas Jasperse; Lotte Lutkenhaus; Emmy Lamers (Lid Lectoraat); Eugene Damen; Esther G.C. Troost; Gerben R. Borst

Purpose/Objective: Most dose-escalation trials in glioblastoma patients integrate the escalated dose throughout the standard course by targeting a specific subvolume. We hypothesize that anatomical changes during irradiation may affect the dose coverage of this subvolume for both proton- and photon-based …

2021-09-28GezondheidArtikel

Characterization of automatic treatment planning approaches in radiotherapy

Geert Wortel; Dave Eekhout; Emmy Lamers (Lid Lectoraat); René van der Bel; Karen Kiers; Terry Wiersma; Tomas Janssen; Eugene Damen

Background and purpose: Automatic approaches are widely implemented to automate dose optimization in radiotherapy treatment planning. This study systematically investigates how to configure automatic planning in order to create the best possible plans. Materials and methods: Automatic plans were generated …

2021-07-13GezondheidArtikel

Multivariable normal tissue complication probability model-based treatment plan optimization for grade 2-4 dysphagia and tube feeding dependence in head and neck radiotherapy

Kierkels, Roel G J; Wopken, Kim; Visser, Ruurd; Korevaar, Erik W; van der Schaaf, Arjen; Bijl, Hendrik P; Langendijk, Johannes A

BACKGROUND AND PURPOSE: Radiotherapy of the head and neck is challenged by the relatively large number of organs-at-risk close to the tumor. Biologically-oriented objective functions (OF) could optimally distribute the dose among the organs-at-risk. We aimed to explore OFs based on multivariable normal …

2016-12AlgemeenArtikel

Prediction model to predict critical weight loss in patients with head and neck cancer during (chemo)radiotherapy

Langius, Jacqueline A.E.; Twisk, Jos; Kampman, Martine; Doornaert, Patricia; Kramer, Mark H.H.; Weijs, Peter J.M. (Lectoraat Voeding En Beweging); Leemans, C. René

OBJECTIVES: Patients with head and neck cancer (HNC) frequently encounter weight loss with multiple negative outcomes as a consequence. Adequate treatment is best achieved by early identification of patients at risk for critical weight loss. The objective of this study was to detect predictive factors …

2016-01AlgemeenArtikel

Evaluation of DVH-based treatment plan verification in addition to gamma passing rates for head and neck IMRT

Visser, Ruurd; Wauben, David J.L.; de Groot, Martijn; Steenbakkers, Roel J.H.M.; Godart, Jeremy; van 't Veld, Aart A.; Langendijk, Johannes A.; Korevaar, Erik W.; Bijl, Hendrik P

Background and purpose: Treatment plan verification of intensity modulated radiotherapy (IMRT) is generally performed with the gamma index (GI) evaluation method, which is difficult to extrapolate to clinical implications. Incorporating Dose Volume Histogram (DVH) information can compensate for this. …

2014-09-01AlgemeenArtikel

The impact of gastrointestinal and genitourinary toxicity on health related quality of life among irradiated prostate cancer patients

Schaake, Wouter (Healthy Ageing, Allied Health Care And Nursing); Wiegman, Erwin M.; de Groot, Martijn; van der Laan, Hans Paul; van der Schans, Cees (Healthy Ageing, Allied Health Care And Nursing); van den Bergh, Alfons C.M.; Langendijk, Johannes A.

PURPOSE: To determine the impact of late radiation-induced toxicity on health-related quality of life (HRQoL) among patients with prostate cancer. PATIENTS AND METHODS: The study sample was composed of 227 patients, treated with external beam radiotherapy. Common Terminology Criteria for Adverse Events …

2014-02-01AlgemeenArtikel

Quality of life among prostate cancer patients: a prospective longitudinal population-based study

Schaake, Wouter (Healthy Ageing, Allied Health Care And Nursing); de Groot, Martijn; Krijnen, Wim (Statistical Techniques For Applied Research); Langendijk, Johannes A.; van den Bergh, Alfons C.M.

Purpose To investigate the course of quality of life (QoL) among prostate cancer patients treated with external beam radiotherapy and to compare the results with QoL of a normal age-matched reference population. Conclusion Prostate cancer patients experience a small worsening of QoL as compared with …

2013-08-01AlgemeenArtikel

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