HBO Kennisbank

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Blood-Based Immune Profiling Combined with Machine Learning Discriminates Psoriatic Arthritis from Psoriasis Patients

Alkema, Wynand (Data Science For Life Science & Health); He, Xuehui; Kaffa, Charlotte; Joosten, Irma; Smeets, Ruben L; Koenen, Hans J P M; Mulder, Michelle L.M.; van den Reek, Juul M.P.A.; Urbano, Paulo C.M.; Wang, Xinhui; van Cranenbroek, Bram; van Rijssen, Esther; Van Den Hoogen, Frank H.J.; de Jong, Elke M. G .J.; Wenink, Mark H.

Psoriasis (Pso) is a chronic inflammatory skin disease, and up to 30% of Pso patients develop psoriatic arthritis (PsA), which can lead to irreversible joint damage. Early detection of PsA in Pso patients is crucial for timely treatment but difficult for dermatologists to implement. We, therefore, aimed …

2021-10-12AlgemeenArtikel

Neurocognitive impairment in a chronically well-suppressed HIV-infected population: the Dutch TREVI cohort study

L.W.J. van den Dries; M.N. Wagener; L.C. Jiskoot; M. Visser; K.R. Robertson; K.S. Adriani; E.C.M. van Gorp

We assessed the value of screening for cognitive abnormalities in a chronically infected HIV population (N = 388) and investigated the association with clinical correlates. The mean age was 48 years (±11), the majority of the patients were male (89%), the median duration of infection was 6 years [interquartile …

2017-08-01GezondheidArtikel

Docosahexaenoyl Serotonin, an endogenously formed n-3 fatty acid-serotonin conjugate has anti-inflammatory properties by attenuating IL-23–IL-17 signalling in macrophages

Jean Paul ten Klooster (Lid Lectoraat); Raymond Pieters (Lector); Mieke Polanda; Zheng Wang; Renger Witkamp; Jocelijn Meijerink; Mark Boekschoten

Abstract from the article: "Conjugates of fatty acids and amines, including endocannabinoids, are known to play important roles as endogenous signaling molecules. Among these, the ethanolamine conjugate of the n-3 poly unsaturated long chain fatty acid (PUFA) docosahexaenoic acid (22:6n-3) (DHA) was …

2016-09-26Gezondheid; …Artikel

The effect of HIV infection on anal and penile human papillomavirus incidence and clearance: a cohort study among MSM

Sofie H. Mooij (Onderzoeker); Daniella K. van Santen (Onderzoeker); Ronald B. Geskus (Onderzoeker); Marianne A.B. van der Sande (Onderzoeker); Roel A. Coutinho (Onderzoeker); Ineke G. Stolte (Onderzoeker); Peter J.F. Snijders (Onderzoeker); Chris J.L.M. Meijer (Onderzoeker); Arjen Speksnijder (Onderzoeker); Henry J.C. de Vries (Onderzoeker); Audrey J. King (Onderzoeker); Arne van Eeden (Onderzoeker); Maarten F. Schim van der Loeff (Onderzoeker)

Objectives: A large portion of anogenital cancers is caused by high-risk human papillomavirus (hrHPV) infections, which are especially common in HIV-infected men. We aimed to compare the incidence and clearance of anal and penile hrHPV infection between HIV-infected and HIV-negative MSM. Design: Analyses …

2016-01-02GezondheidArtikel

For adult patients suffering from HIV/AIDS is Mindfulness Based Stress Reduction an effective adjuvant treatment option to improve immune function and psychological well-being?

Anke Lahaije (Begeleider); Valentine Senoner (Student)

Objective: Mindfulness Based Stress reduction has shown to provide benefits to patients suffering from chronic diseases. Since literature about its effects on HIV/AIDS patients is limited, the objective of the present review is to investigate whether Mindfulness Based Stress Reduction is an effective …

2014GezondheidBachelor

Molecular pathway profiling of T lymphocyte signal transduction pathways; Th1 and Th2 genomic fingerprints are defined by TCR and CD28-mediated signaling

Smeets, Ruben L; Fleuren, Wilco W M; He, Xuehui; Vink, Paul M; Wijnands, Frank; Gorecka, Monika; Klop, Henri; Bauerschmidt, Sussane; Garritsen, Anja; Koenen, Hans J P M; Joosten, Irma; Boots, Annemieke M H; Alkema, Wynand (Data Science For Life Science & Health)

BACKGROUND: T lymphocytes are orchestrators of adaptive immunity. Naïve T cells may differentiate into Th1, Th2, Th17 or iTreg phenotypes, depending on environmental co-stimulatory signals. To identify genes and pathways involved in differentiation of Jurkat T cells towards Th1 and Th2 subtypes we performed …

2012-03-14AlgemeenArtikel

Prednisolone-induced changes in gene-expression profiles in healthy volunteers

Toonen, Erik J M; Fleuren, Wilco W M; Nässander, Ulla; van Lierop, Marie-José C; Bauerschmidt, Susanne; Dokter, Wim H A; Alkema, Wynand (Data Science For Life Science & Health)

BACKGROUND: Prednisolone and other glucocorticoids (GCs) are potent anti-inflammatory and immunosuppressive drugs. However, prolonged use at a medium or high dose is hampered by side effects of which the metabolic side effects are most evident. Relatively little is known about their effect on gene-expression …

2011-07-25AlgemeenArtikel

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