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Drug-induced caspase 8 upregulation sensitises cisplatin-resistant ovarian carcinoma cells to rhTRAIL-induced apoptosis

Duiker, E.; van der Heij-Meijer, Annemieke; van der Bilt, A. R. M.; Meersma, G.J.; Kooi, N.; van der Zee, A.G.J.; de Vries, E.G.E.; de Jong, Steven

Background: Drug resistance is a major problem in ovarian cancer. Triggering apoptosis using death ligands such as tumour necrosis factor-related apoptosis inducing ligand (TRAIL) might overcome chemoresistance. Methods: We investigated whether acquired cisplatin resistance affects sensitivity to recombinant …

2011-04-01AlgemeenArtikel

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Drug-induced caspase 8 upregulation sensitises cisplatin-resistant ovarian carcinoma cells to rhTRAIL-induced apoptosis

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