Hereditary Breast and Ovarian Cancer (HBOC) typically arises from mutations inherited in the germline. BRCA1 and BRCA2 mutaions are predominant contributors to HBOC, accounting for the majority of cases. These mutations are associated with 10% of ovarian cancer cases and 3-5% of breast cancer cases [4]. BRCA1 …

Drought, caused by climate change, poses a significant threat to the production of barley. To ensure high yields, drought adaptation in barley is critical. Roots are primarily responsible for water uptake, and during drought, when water levels are low, deep rooting traits are crucial for developing drought-tolerant …

Arrhythmogenic Cardiomyopathy (ACM), also known as arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is a rare hereditary disease of the heart, where the connective, and fatty tissue is deposited in the muscle tissue of the ventricular myocardium primarily of the right but also left …

De darmflora is onderdeel van de humane microbiota. Alhoewel de volledige samenstelling van de darmflora onbekend is overheersen de bacteriële fyla Bacteriodetes en Firmicutes de volwassen darmflora [10]. Veranderingen zoals onvoldoende lichaamsbeweging of een minder gevarieerd dieet kunnen dysbiose …

Over time memories are believed to undergo a time-dependent reorganization in the brain through a process known as systems consolidation during which they become less dependent on the hippocampus and more dependent on the neocortical structures. This reorganization is accompanied by a generalization …

Owing to the non-toxic, nonimmunogenic effects and high affinity to specific molecules, some single-stranded oligonucleotides, namely aptamers, can be exploited in biochemical applications to deliver bioactive elements and interact with the desired targets. Among many identified aptamers, D#7 was utilized …

Alzheimer's disease (AD) is the common neurodegenerative disorder and the most frequent cause of dementia. The disease accounts around 80% of all dementia diagnoses. The main reason of developing AD is amyloid cascade which starts from missense mutations in APP (amyloid precursor protein), Rho-associated …

Sepsis is a life-threatening organ dysfunction caused by a dysregulated immune response to infection. It is the number one cause of death in the Intensive Care Unit (ICU), accounting for 6 million casualties every year. Unfortunately, all clinical trials in the last decade failed due to the highly complex …

Clonal haematopoiesis of intermediate potential (CHIP) driven by somatic mutations in DNMT3A and TET2 has been recently recognized as a new risk factor for cardiovascular diseases (CVD). The haematopoietic clones with mutations in these genes are frequently found in myeloid malignancies and according …

Cardiovascular diseases (CVDs) are by far the leading cause of death due to non communicable diseases in the world. The development of CVDs in many cases is caused by atherosclerosis. In atherosclerosis, plaques in blood vessels are formed by the excessive accumulation of lipids in the endothelial lining. …