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Improved Efficacy of Oral Immunotherapy Using Non-Digestible Oligosaccharides in a Murine Cow's Milk Allergy Model

Marlotte M. Vonk (Onderzoeker); Mara A.P. Diks (Onderzoeker); Laura Wagenaar (Onderzoeker); J.J. Smit (Onderzoeker); Raymond Pieters (Lector); Johan Garssen (Onderzoeker); Betty C.A.M. van Esch (Onderzoeker); Léon M.J. Knippels (Onderzoeker)

From teh UU repository: "Background: Oral immunotherapy (OIT) is a promising therapeutic approach to treat food allergic patients. However, there are some concerns regarding its safety and long-term efficacy. The use of non-digestible oligosaccharides might improve OIT efficacy since they are known to …

2017GezondheidArtikel

N-Docosahexaenoyl Dopamine, an Endocannabinoid-like Conjugate of Dopamine and the n-3 Fatty Acid Docosahexaenoic Acid, Attenuates Lipopolysaccharide-Induced Activation of Microglia and Macrophages via COX-2

YA Wang (Onderzoeker); P. Plastina (Onderzoeker); Jean-Paul Vincken (Onderzoeker); Renate Jansen (Onderzoeker); Michiel Balvers (Onderzoeker); Jean Paul ten Klooster (Lid Lectoraat); Harry Gruppen (Onderzoeker); Renger Witkamp (Onderzoeker); Jocelijn Meijerink (Onderzoeker)

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.6b00298 From teh publisher: "Several studies indicate that the n-3 long-chain polyunsaturated fatty acid docosahexaenoic acid (DHA) contributes to an attenuated inflammatory status in the development of neurodegenerative disorders, such as Alzheimer’s …

2017GezondheidArtikel

Application of the adverse outcome pathway (AOP) concept to structure the available in vivo and in vitro mechanistic data for allergic sensitization to food proteins

Raymond Pieters (Lector)

From the publisher: "Background: The introduction of whole new foods in a population may lead to sensitization and food allergy. This constitutes a potential public health problem and a challenge to risk assessors and managers as the existing understanding of the pathophysiological processes and the …

2017GezondheidArtikel

Docosahexaenoyl Serotonin, an endogenously formed n-3 fatty acid-serotonin conjugate has anti-inflammatory properties by attenuating IL-23–IL-17 signalling in macrophages

Jean Paul ten Klooster (Lid Lectoraat); Raymond Pieters (Lector); Mieke Polanda; Zheng Wang; Renger Witkamp; Jocelijn Meijerink; Mark Boekschoten

Abstract from the article: "Conjugates of fatty acids and amines, including endocannabinoids, are known to play important roles as endogenous signaling molecules. Among these, the ethanolamine conjugate of the n-3 poly unsaturated long chain fatty acid (PUFA) docosahexaenoic acid (22:6n-3) (DHA) was …

2016-09-26Gezondheid; …Artikel

Prediction of carcinogenic potential of chemicals using repeated-dose (13-week) toxicity data

Mirjam Luijten; Jan van Benthem; E.D. Kroese; Ruud A. Woutersen; Cyrille A.M. Krul (Lector); Ans E.M.F. Soffers; Jan Willem van der Laan

From the article: Abstract Sub-chronic toxicity studies of 163 non-genotoxic chemicals were evaluated in order to predict the tumour outcome of 24-month rat carcinogenicity studies obtained from the EFSA and ToxRef databases. Hundred eleven of the 148 chemicals that did not induce putative preneoplastic …

2016-09-08Gezondheid; …Artikel

Intra- and inter-laboratory validation of an innovative huFcεRIα-RBL-2H3 degranulation assay for in vitro allergenicity assessment of whey hydrolysates

Marjan Gros; Linda Cox; Johan Garssen; Niels de Jong; Diana Kegler; Reiko Teshima; Peter J. Simons; Laura Kruijssen; Manon van Roest; Raymond Pieters (Lector); Léon M.J. Knippels; Marieke Smits (Lid Lectoraat); Marc Teunis (Lid Lectoraat); Karen Knipping; Louis Boon

from the article: "Cow's milk-derived whey hydrolysates are milk substitutes for cow's milk allergic infants. Safety assessment of these hydrolysates is crucial. Currently, huFcεRIα-RBL-2H3 cells, sensitized with serum IgE from cow's milk allergic patients, are used to assess in vitro residual allergenicity. …

2016-02-24Natuur & LandbouwArtikel

The effect of endurance exercise on intestinal integrity in well‐trained healthy men

Lonneke Janssen - Duijghuijsen; Marco Mensink; Kaatje Lenaerts; Ewa Fiedorowicz; Dorien van Dartel; Jurriaan Mes; Yvette Luiking; Harry Wichers; Renger Witkamp; Klaske van Norren; Shirley Kartaram (Lid Lectoraat); Anne Geijsen; Astrid van der Harst; Martie Verschuren; Leon Knippels; Raymond Pieters (Lector)

Exercise is one of the external factors associated with impairment of intestinal integrity, possibly leading to increased permeability and altered absorption. Here, we aimed to examine to what extent endurance exercise in the glycogen‐depleted state can affect intestinal permeability toward small molecules …

2016GezondheidArtikel

Validation; truth or dare! [Abstract].

Marc Teunis (Lid Lectoraat); Cyrille Krul (Lector); Raymond Pieters (Lector)

n.a.

2015-10-16Natuur & LandbouwArtikel

Role of the immune system in DILI

Raymond Pieters (Lector)

n.a. doi:10.1016/j.toxlet.2015.08.109

2015-10-16Techniek; …Artikel

Validation of the innovative ToxTracker® genotoxicity reporter assay

Marc Teunis (Lid Lectoraat); Mieke Smits (Lid Lectoraat); H. Besselink; L.R.A. Jonker; G. Hendriks; E Adriaens

2015-09-29Gezondheid; …Recensie

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