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Type 2 diabetes-related proteins derived from an in vitro model of inflamed fat tissue

A. Sotiriou (Onderzoeker); S. Boeren (Onderzoeker); S. Vaessen (Lid Lectoraat); J. Vervoort (Onderzoeker); R. Pieters (Onderzoeker); Jean Paul ten Klooster (Lid Lectoraat)

2018-04-15GezondheidArtikel

Glycation of the Major Milk Allergen β-Lactoglobulin Changes Its Allergenicity by Alterations in Cellular Uptake and Degradation

Marija Perusko (Onderzoeker); Manon van Roest (Onderzoeker); Dragana Stanic-Vucinic (Onderzoeker); Peter J. Simons (Onderzoeker); Raymond Pieters (Lector); Tanja Cirkovic-Velickovic (Onderzoeker); Joost Smit (Onderzoeker)

From the article: "Scope: During food processing, the Maillard reaction ( М R) may occur, resulting in the formation of glycated proteins. Glycated proteins are of particular importance in food allergies because glycation may influence interactions with the immune system. This study compared native …

2018GezondheidArtikel

Application of Caenorhabditis elegans (nematode) and Danio rerio embryo (zebrafish) as model systems to screen for developmental and reproductive toxicity of Piperazine compounds

Peter I. Racza (Onderzoeker); Marjolein Wildwater (Onderzoeker); Martijn Rooseboom (Onderzoeker); Engelien Kerkhof (Onderzoeker); Raymond Pieters (Lector); Elena Santidrian Yebra-Pimentela (Onderzoeker); Ron P. Dirks (Onderzoeker); Herman P. Spaink (Onderzoeker); Chantal Smulders (Onderzoeker); Graham F. Whale (Onderzoeker)

From the article: "To enable selection of novel chemicals for new processes, there is a recognized need for alternative toxicity screening assays to assess potential risks to man and the environment. For human health hazard assessment these screening assays need to be translational to humans, have …

2017-06-27GezondheidArtikel

The Isolated Chicken Eye test to replace the Draize test in rabbits

Menk Prinsen (Onderzoeker); Coenraad F.M. Hendriksen (Onderzoeker); Cyrille Krul (Lector); Ruud A. Woutersen (Onderzoeker)

Prinsen MK, Hendriksen CFM, Krul CAM, Woutersen RA. Regul Toxicol Pharmacol. 2017 Apr;85:132-149. doi: 10.1016/j.yrtph.2017.01.009. Epub 2017 Feb 10. PMID:28192172

2017-02-10GezondheidArtikel

Indole-3-carbinol, a plant nutrient and AhR-Ligand precursor, supports oral tolerance against OVA and improves peanut allergy symptoms in mice

Christiane Hammerschmidt-Kamper (Onderzoeker); Daniel Biljes (Onderzoeker); Katja Merches (Onderzoeker); Irina Steiner (Onderzoeker); Daldrup Thomas (Onderzoeker); Marianne Bol-Schoenmakers (Onderzoeker); Raymond Pieters (Lector); Charlotte Esser (Onderzoeker)

From PLoS website: In general, dietary antigens are tolerated by the gut associated immune system. Impairment of this so-called oral tolerance is a serious health risk. We have previously shown that activation of the ligand-dependent transcription factor aryl hydrocarbon receptor (AhR) by the environmental …

2017GezondheidArtikel

Benefits: Tradition of Use, Experimental Models and Human Studies to Support Health Claims of Botanicals In Food Supplements containing botanicals

Raymond Pieters (Lector)

From the website of the publisher: "Botanicals, which are basis of many plant food supplements (PFS), constitute the major part of worldwide and historically founded traditional medicines (TM) used to cure diseases and maintain health. A recently published trilogy called “The Art and Science of Traditional …

2017GezondheidBoekdeel

Regional Expression Levels of Drug Transporters and Metabolizing Enzymes along the Pig and Human Intestinal Tract and Comparison with Caco-2 Cells

Stefan Vaessen (Lid Lectoraat); M.M.H. van Lipzig (Onderzoeker); Raymond Pieters (Lector); Cyrille Krul (Lector); Heleen Wortelboer (Onderzoeker); E. van de Steeg (Onderzoeker)

From TU Delft repository: "Intestinal transporter proteins and metabolizing enzymes play a crucial role in the oral absorption of a wide variety of drugs. The aim of the current study was to characterize better available intestinal in vitro models by comparing expression levels of these proteins and …

2017GezondheidArtikel

Human lung epithelial cell cultures for analysis of inhaled toxicants

P.S. Hiemstra (Onderzoeker); G. Grootaers (Onderzoeker); A.M. van der Does (Onderzoeker); Cyrille Krul (Lector); Ingeborg M. Kooter

doi: 10.1016/j.tiv.2017.11.005 / PMID:29155131

2017GezondheidArtikel

N-Docosahexaenoyl Dopamine, an Endocannabinoid-like Conjugate of Dopamine and the n-3 Fatty Acid Docosahexaenoic Acid, Attenuates Lipopolysaccharide-Induced Activation of Microglia and Macrophages via COX-2

YA Wang (Onderzoeker); P. Plastina (Onderzoeker); Jean-Paul Vincken (Onderzoeker); Renate Jansen (Onderzoeker); Michiel Balvers (Onderzoeker); Jean Paul ten Klooster (Lid Lectoraat); Harry Gruppen (Onderzoeker); Renger Witkamp (Onderzoeker); Jocelijn Meijerink (Onderzoeker)

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.6b00298 From teh publisher: "Several studies indicate that the n-3 long-chain polyunsaturated fatty acid docosahexaenoic acid (DHA) contributes to an attenuated inflammatory status in the development of neurodegenerative disorders, such as Alzheimer’s …

2017GezondheidArtikel

The efficacy of oral and subcutaneous antigen-specific immunotherapy in murine cow's milk- and peanut allergy models

Marlotte M. Vonk (Onderzoeker); Laura Wagenaar (Onderzoeker); Raymond Pieters (Lector); Léon M.J. Knippels (Onderzoeker); L.E.M. Willemsen (Onderzoeker); J.J. Smit (Onderzoeker); BCAM van Esch (Onderzoeker); J. Garssen (Onderzoeker)

From Pubmed: " BACKGROUND: Antigen-specific immunotherapy (AIT) is a promising therapeutic approach for both cow's milk allergy (CMA) and peanut allergy (PNA), but needs optimization in terms of efficacy and safety. AIM: Compare oral immunotherapy (OIT) and subcutaneous immunotherapy (SCIT) in …

2017GezondheidArtikel

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