Samenvatting

In collaboration with Eindhoven University of Technology, the goal is to synthesize water-soluble supramolecular fiber components (hydrogels) based on the BTA for mimicking the ECM. Is these BTA components the tetraethylene glycol units would be replaced by mono- or disaccharides, e.g. glucose or cellobiose. In order to be able to introduce functionalities in these fiber components, we would like to introduce an azide into the glycosyl donors. This azide can then be used as a handle to introduce other functionalities, e.g. fluorophore, growth factors or antibiotics for the organoids. Furthermore, kinetic studies could be done with these fibers when they are conjugated to fluorophores.