Samenvatting

Movement disorders in dementia are not well known yet they have a devastating effect on the quality of life and the abilities of a person with dementia. Paratonia is one of these movement disorders that are already present in 10% of the population with dementia in the early stages and increase up to 100% in the late stages. Paratonia is caused by central nervous system pathology, yet peripheral biomechanical changes due to Advanced Glycation Endproducts (AGEs) are also responsible for further deterioration of motor control in dementia. Physical activity can prevent the accumulation of AGEs.