Abstract from the article: "Conjugates of fatty acids and amines, including endocannabinoids, are known to play important roles as endogenous signaling molecules. Among these, the ethanolamine conjugate of the n-3 poly unsaturated long chain fatty acid (PUFA) docosahexaenoic acid (22:6n-3) (DHA) was …

Niet-invasieve diagnostische beeldvormende technieken zijn van belang bij het opsporen van kwetsbare plaques voor de preventie van een herseninfarct. Het doel van dit onderzoek is het valideren van compound strain imaging voor het meten van de kwetsbaarheid van atherosclerotische carotis plaques bij …

Objective:This study investigated whether visual function is associated with cognitive activity engagement and mild cognitive impairment in middle-aged and elderly individuals. Method:This cross-sectional study was conducted on 120 individuals aged 50–89. The Florida Cognitive Activity Scale (FCAS) …

This study investigates the social relations within the traditional African family compound, its relation to life in public space/the public domain and compares the impact on these relationships as a result of changes in current developments. First, a detailed description is given of the main location, …

The current situation of the Icelandic dairy production and the desire of the Icelandic farmers are the occasion of this study. The main objective of the study is to identify opportunities in feeding management to improve the production of the Icelandic dairy farms. The four important subjects within …

In dit onderzoek is er gekeken naar de mogelijke machinale oplossingen voor het afwateren, drogen, koelen en verpakken van rubber-compound granulaat wat met behulp van een continu productie proces vervaardigd wordt. Op verzoek van de opdrachtgever is er onderzoek gedaan in twee richtingen; een onderzoek …

Glucocorticoids (GCs) such as prednisolone are potent immunosuppressive drugs but suffer from severe adverse effects, including the induction of insulin resistance. Therefore, development of so-called Selective Glucocorticoid Receptor Modulators (SGRM) is highly desirable. Here we describe a non-steroidal …

An efficient four-step biotransformation-mediated synthesis of (1S)-1-(2,6-dichloro-3-fluorophenyl)ethanol in enantiomerically pure form is described. This compound is a key intermediate required for the preparation of PF-2341066, a potent inhibitor of c-Met/ALK that is currently in clinical development. …

From Science direct: One of the nanowires was covered with a 2-Hydroxyethyl methacrylate based compound to prevent hydrogen from reaching the wire. The compound was dried by a UV source and tested in chamber for comparison with previous measurements. The results shows that temperature effects can be …

Introduction: To reduce continuously increasing costs in drug development, adverse effects of drugs need to be detected as early as possible in the process. In recent years, compound-induced gene expression profiling methodologies have been developed to assess compound toxicity, including Gene Ontology …